The neurobiology and neural circuitry of cognitive changes in Parkinson's disease revealed by functional neuroimaging
Identifieur interne : 001350 ( Main/Exploration ); précédent : 001349; suivant : 001351The neurobiology and neural circuitry of cognitive changes in Parkinson's disease revealed by functional neuroimaging
Auteurs : Nicola J. Ray [Canada] ; Antonio P. Strafella [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2012-10.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Animals, Brain (pathology), Brain (physiopathology), Cognition, Cognition Disorders (etiology), Emission tomography, Executive function, Humans, Nerve Net (pathology), Nerve Net (physiopathology), Nervous system diseases, Neurobiology, Neuroimaging, Nuclear magnetic resonance imaging, PD, PET, Parkinson Disease (complications), Parkinson Disease (pathology), Parkinson disease, Positron emission tomography, cognition, executive functions, fMRI.
- MESH :
- complications : Parkinson Disease.
- etiology : Cognition Disorders.
- pathology : Brain, Nerve Net, Parkinson Disease.
- physiopathology : Brain, Nerve Net.
- Animals, Humans, Neurobiology, Neuroimaging.
Abstract
Patients with Parkinson's disease (PD) often develop a spectrum of cognitive symptoms that can evolve into dementia. Dopamine (DA) replacement medications, though improving motor symptoms, can exert both positive and negative effects on cognitive ability, depending on the severity of the disease and the specific skill being tested. By considering the behavioral and clinical aspects of disease‐ and treatment‐mediated changes in cognition alongside the pathophysiology of PD, an understanding of the factors that govern the heterogeneous expression of cognitive impairment in PD is beginning to emerge. Here, we review the neuroimaging studies revealing the neural correlates of cognitive changes after DA loss and DA replacement as well as those that may accompany the conversion from milder stages of cognitive impairment to frank dementia. © 2012 Movement Disorder Society
Url:
- https://api-v5.istex.fr/document/2B94D927673B3C8D8F660A62E005DA3F7D9E0C4B/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452226
DOI: 10.1002/mds.25173
Affiliations:
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Le document en format XML
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Dopamine (DA) replacement medications, though improving motor symptoms, can exert both positive and negative effects on cognitive ability, depending on the severity of the disease and the specific skill being tested. By considering the behavioral and clinical aspects of disease‐ and treatment‐mediated changes in cognition alongside the pathophysiology of PD, an understanding of the factors that govern the heterogeneous expression of cognitive impairment in PD is beginning to emerge. Here, we review the neuroimaging studies revealing the neural correlates of cognitive changes after DA loss and DA replacement as well as those that may accompany the conversion from milder stages of cognitive impairment to frank dementia. © 2012 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Ray, Nicola J" sort="Ray, Nicola J" uniqKey="Ray N" first="Nicola J." last="Ray">Nicola J. Ray</name></noRegion><name sortKey="Ray, Nicola J" sort="Ray, Nicola J" uniqKey="Ray N" first="Nicola J." last="Ray">Nicola J. Ray</name><name sortKey="Ray, Nicola J" sort="Ray, Nicola J" uniqKey="Ray N" first="Nicola J." last="Ray">Nicola J. Ray</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name><name sortKey="Strafella, Antonio P" sort="Strafella, Antonio P" uniqKey="Strafella A" first="Antonio P." last="Strafella">Antonio P. Strafella</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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